Could This Anti-Diabetic Drug Be the Key to Slowing Aging?
Written by Ayebamiebi Yousuo
Introduction
Diabetes Mellitus is a non-communicable disease characterized by abnormally elevated blood glucose with a strong genetic and lifestyle factor that has plagued the human race for years. With the increase in the consumption of junk and sedentary lifestyle accompanied by genetic factors, this metabolic disorder has become more pronounced leading to the discovery and development of various medications(Insulin analogs, Sulphonylureas, Biguanides, GLP-1 ReceptorAgonist, e.t.c) that are effective for the management of this condition.
These discoveries and developments have led scientists to the discovery of a drug that beyond controlling the body's glucose level might just have some significant anti-aging effect.
The Big Question
The big question is, "What drug is it?" Metformin it is! Metformin, which is a biguanide, and the only biguanide that is currently in use due to its safety profile, has been seen to mimic calorie restriction, and as such has earned it the term, "Calorie Restriction Mimetic (CRM).”
Over the years scientists have researched and experimented on various means to slow down aging, and the means that has stood out and seen to be the most effective is calorie restriction. But we all know calorie restriction is not so palatable, especially in this generation. So how do we eat our cake and have it? That's where metformin comes in. It produces the same effects such as cardioprotective, hepatoprotective, and anti-malignant effects, as calorie restriction without necessarily restricting calories.
Conclusion
Much research is still ongoing to pursue this anti-aging hypothesis of metformin. In the meantime, to ensure good health and longevity humans must continue to seek calorie restriction habits and an active lifestyle.
References
Kalra, S., Unnikrishnan, A. G., & Sahay, R. (2012a, July). Metformin and the promise of geroprotection. Indian journal of endocrinology and metabolism.
https://pmc.ncbi.nlm.nih.gov/articles/PMC3401742/
Written by Ayebamiebi Yousuo from MEDILOQUY